WO2018087347: Use of non-transition metal coordinated dipyridoxyl compounds to prevent and treat chemotherapy-induced PSN
Inventors: Karlsson JOG, Jynge P, Andersson RGG
PCT filed: 2017
Granted: USA (US10888553B2), Europe (EP3538155B1), China (CN1101396773B), Japan (JP7065866132
Assignee: Karlsson-Tuner Invest AS
Abstract
There is disclosed a platinum ion chelating dipyridoxyl compound, or a pharmaceutically acceptable salt thereof, wherein the dipyridoxyl compound is uncoordinated or coordinated with a metal ion which is not a transition metal, for prevention or treatment of chemotherapy drug induced peripheral sensory neuropathy in a patient, wherein the chemotherapy drug comprises platinum ions. An example of such a chemotherapy drug is oxaliplatin. The drawbacks of previous metal complexed compounds containing manganese ions are eliminated. A more frequent use of the drug is possible since the problem in the prior art with accumulated manganese neurotoxicity is eliminated. The compounds can be administered both temporally and spatially separately from chemotherapy.
WO2013102806A1: Calmangafodipir, a new chemical entity, and other mixed metal complexes, methods of preparation, compositions, and methods of treatment
Inventors: Karlsson JOG, Reineke K, Kurz T, Andersson RGG et al.
PCT filed: 2012
Granted: "Worldwide"
Assignee: PledPharma AB
Abstract
A mixed metal complex of a compound of Formula I, or a salt thereof, wherein the mixed metals comprise a Group
III-XII transition metal and a Group II metal: (Formula I) (I) wherein X, R 1, R2, R3, and R4 are as defined herein, is produced in a one step crystallization from a solution of the Group III-XII transition metal, the Group II metal, and a compound of Formula I.
Methods for treatment of a pathological condition in a patient, for example, a pathological condition caused by the presence of oxygen-derived free radicals, comprises administering the mixed metal complex to the patient
WO2011004325A1: Pharmaceutical compositions and therapeutic methods employing a combination of a manganese complex compound and a non-manganese complex form of the compound
Inventors: Karlsson JOG, Andersson RGG
PCT filed: 2011
Granted: "Worldvide"
Assignee: PledPharma AB
WO2009078794A1: Compounds for use in the treatment of cancer
Inventors: Karlsson JOG, Kurz T, Andersson RGG
PCT filed: 2007
Granted: "Worldwide"
Assignee: PledPharma AB