PATENT

WO2018087347: Use of non-transition metal coordinated dipyridoxyl compounds to prevent and treat chemotherapy-induced PSN

Inventors: Karlsson JOG, Jynge P, Andersson RGG 

PCT filed: 2017

Granted: USA (US10888553B2), Europe (EP3538155B1), China (CN1101396773B), Japan (JP7065866132)

Assignee: Karlsson-Tuner Invest AS

Abstract

There is disclosed a platinum ion chelating dipyridoxyl compound, or a pharmaceutically acceptable salt thereof, wherein the dipyridoxyl compound is uncoordinated or coordinated with a metal ion which is not a transition metal, for prevention or treatment of chemotherapy drug induced peripheral sensory neuropathy in a patient, wherein the chemotherapy drug comprises platinum ions. An example of such a chemotherapy drug is oxaliplatin. The drawbacks of previous metal complexed compounds containing manganese ions are eliminated. A more frequent use of the drug is possible since the problem in the prior art with accumulated manganese neurotoxicity is eliminated. The compounds can be administered both temporally and spatially separately from chemotherapy.